Reactive Mesothelial Cells In Pleural Fluid Cytology

The article deals with cytopathology specimens from spaces lined with mesothelium i e.

Reactive mesothelial cells in pleural fluid cytology.

The distinction between reactive and malignant mesothelial cells has long been a challenge in effusion cytology. Normally mesotheial cells present only along surface and not in underlying tissue. Epithelial or lining cells most commonly mesothelial cells 1 the appearance and presentation of nucleated cells found in pleural fluid and whether they are considered common benign or abnormal is discussed below. Papanicolaou x100 breast adenocarcinoma cells in pleural effusion.

An introduction to cytopathology is in the cytopathology article. Numerous mesothelial cells are seen in this pleural fluid from a dog with a transudative effusion with concurrent diapedesis of red blood cells or hemorrhage. Neoplastic transformation of mesothelial cells results in malignant mesothelioma an aggressive tumor especially the pleura. Atypical mesothelial cell proliferation.

Hyperplastic mesothelial cells with slightly enlarged nuclei micronucleoli and a clear space or window between adjacent cells present singly and in small clusters. Larger clusters of hyperplastic mesothelial cells showing mildly nuclear atypia with small nucleoli. Common cells present in pleural fluid include neutrophils lymphocytes monocytes mesothelial cells and red blood. 9 14 these studies suggest that 2.

It deals with pericardial fluid peritoneal fluid and pleural fluid. The mesothelial cells have central round nuclei with a moderate amount of light purple cytoplasm and a corona or fringe to the cytoplasmic borders. The many faces of reactive mesothelial cells. Mesothelial cytopathology is a large part of cytopathology.

Bap1 a new marker that is helpful in distinguishing reactive mesothelial cells from malignant mesothelioma. Mesothelial cells form conspicuous layer of regularly spaced bland cuboidal cells along pleural surface. Reactive pleural effusion showing acute and chronic cells normal mesothelial cells and alveolar macrophages in aggregates and dispersed cells with rounded nuclei and vacuolated cytoplasm.